Is Orkambi Worth It?


What Is Orkambi?

Ivacaftor and lumacaftor is used to treat cystic fibrosis in adults and children who are at least 6 years old.

Ivacaftor and lumacaftor is for use only in patients with a specific gene mutation related to cystic fibrosis. Before you take ivacaftor, you may need a medical test to make sure you have this gene mutation.

Ivacaftor and lumacaftor may also be used for purposes not listed in this medication guide.

Serious drug interactions can occur when certain medicines are used together with ivacaftor and lumacaftor.Tell each of your healthcare providers about all medicines you use now, and any medicine you start or stop using.

You should not use this medicine if you are allergic to ivacaftor or lumacaftor.

Some medicines can interact with ivacaftor and lumacaftor and should not be used at the same time.Your doctor may need to change your treatment plan if you use any of the following drugs:

  • rifabutin or rifampin;
  • St. John's wort;
  • medicine to prevent organ transplant rejection--everolimus (Zortress), sirolimus, tacrolimus;
  • a sedative--triazolam or oral midazolam; or
  • seizure medicine--carbamazepine, phenobarbital, phenytoin.

To make sure ivacaftor and lumacaftor is safe for you, tell your doctor if you have:

  • liver disease;
  • kidney disease;
  • high blood pressure;
  • asthma or other lung disease; or
  • if you have had an organ transplant.

This medicine is not expected to harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.

Use a barrier form of birth control (condom or diaphragm with spermicide). Hormonal contraception (birth control pills, injections, implants, and skin patches, and vaginal rings) may not be effective enough to prevent pregnancy during your treatment.

It is not known whether ivacaftor and lumacaftor passes into breast milk or if it could harm a nursing baby. Tell your doctor if you are breast-feeding a baby.

Ivacaftor and lumacaftor is not approved for use by anyone younger than 12 years old.

Orkambi Side Effects

Get emergency medical help if you havesigns of an allergic reaction:hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • shortness of breath, tightness in your chest; or
  • liver problems--nausea, upper stomach pain, itching, tired feeling, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).

Common side effects may include:

  • breathing problems;
  • feeling tired;
  • nausea, gas, diarrhea;
  • rash;
  • flu symptoms;
  • changes in your menstrual periods; or
  • cold symptoms such as runny or stuffy nose, sinus pain, sore throat.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Orkambi Interactions

This medicine may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.

Tell your doctor about all your current medicines and any you start or stop using, especially:

  • an antibiotic--clarithromycin, erythromycin, telithromycin; or
  • antifungal medicine--itraconazole, ketoconazole, posaconazole, voriconazole.

Other drugs may interact with ivacaftor and lumacaftor, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.

Orkambi Dosage

Ivacaftor and lumacaftor is usually taken every 12 hours. Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended.

Read all patient information, medication guides, and instruction sheets provided to you. Ask your doctor or pharmacist if you have any questions.

Take this medicine with a food that contains fat, such as butter, peanut butter, eggs, avocados, nuts, whole milk, cheese, yogurt, or cheese pizza. Follow your doctor's dosing instructions very carefully.

Take your doses at regular intervals, 12 hours apart. This will keep a steady amount of the drug in your body at all times.

You will need frequent blood tests to check your liver function. Your blood pressure may also need to be checked often.

A child using this medicine may need frequent eye exams.

Store at room temperature away from moisture and heat. Keep each tablet in its daily blister strip until you are ready to take your dose.

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Take the missed dose as soon as you remember. If you are more than 6 hours late, skip the missed dose.Do nottake extra medicine to make up the missed dose.

Be sure to take a missed dose with a food that contains fat.

If you miss doses or stop taking ivacaftor and lumacaftor for more than 1 week, call your doctor before you start taking the medicine again. You may need a different dose.

Copyright 1996-2019 Cerner Multum, Inc.

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Date: 30.11.2018, 03:20 / Views: 51443